The orphan nuclear receptor LXRα is positively and negatively regulated by distinct products of mevalonate metabolism

LXRα is an orphan member of the nuclear hormone receptor superfamily that displays constitutive transcriptional activity. We reasoned that this activity may result from the production of an endogenous activator that is a component of intermediary metabolism. The use of metabolic inhibitors revealed...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Forman, Barry Marc, Ruan, Benfang, Chen, Jasmine, Schroepfer, George J., Evans, Ronald M.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1997
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23411/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9380679/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.20.10588
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