The orphan nuclear receptor LXRα is positively and negatively regulated by distinct products of mevalonate metabolism
LXRα is an orphan member of the nuclear hormone receptor superfamily that displays constitutive transcriptional activity. We reasoned that this activity may result from the production of an endogenous activator that is a component of intermediary metabolism. The use of metabolic inhibitors revealed...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1997
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23411/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9380679/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.20.10588 |
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