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Structure of Alzheimer’s disease amyloid precursor protein copper-binding domain at atomic resolution

Amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimer’s disease, as its cleavage generates the Aβ peptide that is toxic to cells. APP is able to bind Cu(2+) and reduce it to Cu(+) through its copper-binding domain (CuBD). The interaction between Cu(2+) and APP leads t...

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Bibliografiske detaljer
Main Authors: Kong, Geoffrey Kwai-Wai, Adams, Julian J., Cappai, Roberto, Parker, Michael W.
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2339725/
https://ncbi.nlm.nih.gov/pubmed/17909280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309107041139
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