Llwytho...
Structure of Alzheimer’s disease amyloid precursor protein copper-binding domain at atomic resolution
Amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimer’s disease, as its cleavage generates the Aβ peptide that is toxic to cells. APP is able to bind Cu(2+) and reduce it to Cu(+) through its copper-binding domain (CuBD). The interaction between Cu(2+) and APP leads t...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
International Union of Crystallography
2007
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2339725/ https://ncbi.nlm.nih.gov/pubmed/17909280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309107041139 |
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