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Structure of Alzheimer’s disease amyloid precursor protein copper-binding domain at atomic resolution
Amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimer’s disease, as its cleavage generates the Aβ peptide that is toxic to cells. APP is able to bind Cu(2+) and reduce it to Cu(+) through its copper-binding domain (CuBD). The interaction between Cu(2+) and APP leads t...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Union of Crystallography
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2339725/ https://ncbi.nlm.nih.gov/pubmed/17909280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309107041139 |
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