The Modulation of Transthyretin Tetramer Stability by Cysteine 10 Adducts and the Drug Diflunisal: DIRECT ANALYSIS BY FLUORESCENCE-DETECTED ANALYTICAL ULTRACENTRIFUGATION

Transthyretin (TTR) is normally a stable plasma protein. However, in cases of familial TTR-related amyloidosis and senile systemic amyloidosis (SSA), TTR is deposited as amyloid fibrils, leading to organ dysfunction and possibly death. The mechanism by which TTR undergoes the transition from stable,...

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Autors principals: Kingsbury, Jonathan S., Laue, Thomas M., Klimtchuk, Elena S., Théberge, Roger, Costello, Catherine E., Connors, Lawreen H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2335343/
https://ncbi.nlm.nih.gov/pubmed/18326041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709638200
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