Targeting the MEK1 Cascade in Lung Epithelium Inhibits Proliferation and Fibrogenesis by Asbestos

The extracellular signal–regulated kinases 1 and 2 (ERK1/2) are phosphorylated after inhalation of asbestos. The effect of blocking this signaling pathway in lung epithelium is unclear. Asbestos-exposed transgenic mice expressing a dominant-negative mitogen-activated protein kinase kinase-1 (dnMEK1)...

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Main Authors: Manning, Christopher B., Sabo-Attwood, Tara, Robledo, Raymond F., MacPherson, Maximilian B., Rincón, Mercedes, Vacek, Pamela, Hemenway, David, Taatjes, Douglas J., Lee, Patty J., Mossman, Brooke T.
Format: Artigo
Jezik:Inglês
Izdano: American Thoracic Society 2008
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2335340/
https://ncbi.nlm.nih.gov/pubmed/18192500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2007-0382OC
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