A Protein Kinase Cδ-Dependent Protein Kinase D Pathway Modulates ERK1/2 and JNK1/2 Phosphorylation and Bim-Associated Apoptosis by Asbestos

Inhalation of asbestos and oxidant-generating pollutants causes injury and compensatory proliferation of lung epithelium, but the signaling mechanisms that lead to these responses are unclear. We hypothesized that a protein kinase (PK)Cδ-dependent PKD pathway was able to regulate downstream mitogen-...

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Detalhes bibliográficos
Main Authors: Buder-Hoffmann, Sylke A., Shukla, Arti, Barrett, Trisha F., MacPherson, Maximilian B., Lounsbury, Karen M., Mossman, Brooke T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630554/
https://ncbi.nlm.nih.gov/pubmed/19116364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080180
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