Asbestos-Induced Peribronchiolar Cell Proliferation and Cytokine Production Are Attenuated in Lungs of Protein Kinase C-δ Knockout Mice

The signaling pathways leading to the development of asbestos-associated diseases are poorly understood. Here we used normal and protein kinase C (PKC)-δ knockout (PKCδ(−/−)) mice to demonstrate multiple roles of PKC-δ in the development of cell proliferation and inflammation after inhalation of chr...

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Detalhes bibliográficos
Main Authors: Shukla, Arti, Lounsbury, Karen M., Barrett, Trisha F., Gell, Joanna, Rincon, Mercedes, Butnor, Kelly J., Taatjes, Douglas J., Davis, Gerald S., Vacek, Pamela, Nakayama, Keiichi I., Nakayama, Keiko, Steele, Chad, Mossman, Brooke T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2007
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1762688/
https://ncbi.nlm.nih.gov/pubmed/17200189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060381
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