Osteopontin Modulates Inflammation, Mucin Production, and Gene Expression Signatures After Inhalation of Asbestos in a Murine Model of Fibrosis

Inflammation and lung remodeling are hallmarks of asbestos-induced fibrosis, but the molecular mechanisms that control these events are unclear. Using laser capture microdissection (LCM) of distal bronchioles in a murine asbestos inhalation model, we show that osteopontin (OPN) is up-regulated by br...

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Detalhes bibliográficos
Main Authors: Sabo-Attwood, Tara, Ramos-Nino, Maria E., Eugenia-Ariza, Maria, MacPherson, Maximilian B., Butnor, Kelly J., Vacek, Pamela C., McGee, Sean P., Clark, Jessica C., Steele, Chad, Mossman, Brooke T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081197/
https://ncbi.nlm.nih.gov/pubmed/21514415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.01.048
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