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STAT3 Regulates ABCA3 Expression and Influences Lamellar Body Formation in Alveolar Type II Cells

ATP-Binding Cassette A3 (ABCA3) is a lamellar body associated lipid transport protein required for normal synthesis and storage of pulmonary surfactant in type II cells in the alveoli. In this study, we demonstrate that STAT3, activated by IL-6, regulates ABCA3 expression in vivo and in vitro. ABCA3...

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Détails bibliographiques
Auteurs principaux: Matsuzaki, Yohei, Besnard, Valérie, Clark, Jean C., Xu, Yan, Wert, Susan E., Ikegami, Machiko, Whitsett, Jeffrey A.
Format: Artigo
Langue:Inglês
Publié: American Thoracic Society 2008
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2335336/
https://ncbi.nlm.nih.gov/pubmed/18096869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2007-0311OC
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