Expression, purification and crystallization of a human tau-tubulin kinase 2 that phosphorylates tau protein

Tau-tubulin kinase 2 (TTBK2) is a Ser/Thr kinase that putatively phosphorylates residues Ser208 and Ser210 (numbered according to a 441-residue human tau isoform) in tau protein. Functional analyses revealed that a recombinant kinase domain (residues 1–331) of human TTBK2 expressed in insect cells w...

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Autori principali: Kitano-Takahashi, Michiko, Morita, Hiroyuki, Kondo, Shin, Tomizawa, Kayoko, Kato, Ryohei, Tanio, Michikazu, Shirota, Yoshiko, Takahashi, Hiroshi, Sugio, Shigetoshi, Kohno, Toshiyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: International Union of Crystallography 2007
Soggetti:
Crystallization Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2335129/
https://ncbi.nlm.nih.gov/pubmed/17620722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309107028783
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