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A structure-based mechanism for benzalacetone synthase from Rheum palmatum

Benzalacetone synthase (BAS), a plant-specific type III polyketide synthase (PKS), catalyzes a one-step decarboxylative condensation of malonyl-CoA and 4-coumaroyl-CoA to produce the diketide benzalacetone. We solved the crystal structures of both the wild-type and chalcone-producing I207L/L208F mut...

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Hlavní autoři: Morita, Hiroyuki, Shimokawa, Yoshihiko, Tanio, Michikazu, Kato, Ryohei, Noguchi, Hiroshi, Sugio, Shigetoshi, Kohno, Toshiyuki, Abe, Ikuro
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818918/
https://ncbi.nlm.nih.gov/pubmed/20080733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909982107
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