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Probing the role of packing specificity in protein design

By using a protein-design algorithm that quantitatively considers side-chain packing, the effect of specific steric constraints on protein design was assessed in the core of the streptococcal protein G β1 domain. The strength of packing constraints used in the design was varied, resulting in core se...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Dahiyat, Bassil I., Mayo, Stephen L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1997
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23334/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9294182/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.19.10172
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