Rational design of a scytalone dehydratase-like enzyme using a structurally homologous protein scaffold

The generation of enzymes to catalyze specific reactions is one of the more challenging problems facing protein engineers. Structural similarities between the enzyme scytalone dehydratase with nuclear transport factor 2 (NTF2) suggested the potential for NTF2 to be re-engineered into a scytalone deh...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Nixon, Andrew E., Firestine, Steven M., Salinas, Frank G., Benkovic, Stephen J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22334/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10097077/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.7.3568
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