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Substitution of a mutant α(2a)-adrenergic receptor via “hit and run” gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo
Norepinephrine contributes to antinociceptive, sedative, and sympatholytic responses in vivo, and α(2) adrenergic receptor (α(2)AR) agonists are used clinically to mimic these effects. Lack of subtype-specific agonists has prevented elucidation of the role that each α(2)AR subtype (α(2A), α(2B), and...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The National Academy of Sciences of the USA
1997
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC23306/ https://ncbi.nlm.nih.gov/pubmed/9275232 |
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