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Heterozygous α(2A)-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists
Genetic manipulation of the α(2A)-adrenergic receptor (α(2A)-AR) in mice has revealed the role of this subtype in numerous responses, including agonist-induced hypotension and sedation. Unexpectedly, α(2)-agonist treatment of mice heterozygous for the α(2A)-AR (α(2A)-AR(+/−)) lowers blood pressure w...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC129469/ https://ncbi.nlm.nih.gov/pubmed/12205290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.122368499 |
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