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Heterozygous α(2A)-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists

Genetic manipulation of the α(2A)-adrenergic receptor (α(2A)-AR) in mice has revealed the role of this subtype in numerous responses, including agonist-induced hypotension and sedation. Unexpectedly, α(2)-agonist treatment of mice heterozygous for the α(2A)-AR (α(2A)-AR(+/−)) lowers blood pressure w...

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Autors principals: Tan, Christopher M., Wilson, Matthew H., MacMillan, Leigh B., Kobilka, Brian K., Limbird, Lee E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2002
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC129469/
https://ncbi.nlm.nih.gov/pubmed/12205290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.122368499
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