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Phage display of a catalytic antibody to optimize affinity for transition-state analog binding

Catalytic antibodies have shown great promise for catalyzing a tremendously diverse set of natural and unnatural chemical transformations. However, few catalytic antibodies have efficiencies that approach those of natural enzymes. In principle, random mutagenesis procedures such as phage display cou...

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Bibliografische gegevens
Hoofdauteurs: Baca, Manuel, Scanlan, Thomas S., Stephenson, Robert C., Wells, James A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences of the USA 1997
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC23305/
https://ncbi.nlm.nih.gov/pubmed/9294163
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