A New Twist In TCR Diversity Revealed By A Forbidden αβ TCR

We report crystal structures of a negatively-selected TCR that recognizes two I-A(u)-restricted myelin basic protein peptides and one of its pMHC ligands. Unusual CDR structural features revealed by our analyses identify a previously unrecognized mechanism by which the highly variable CDR3 regions d...

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Detalhes bibliográficos
Main Authors: McBeth, Christine, Seamons, Audrey, Pizarro, Juan C., Fleishman, Sarel J., Baker, David, Kortemme, Tanja, Goverman, Joan M., Strong, Roland K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2330282/
https://ncbi.nlm.nih.gov/pubmed/18155234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.11.020
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