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A Quantitative High-Throughput Screen Identifies Potential Epigenetic Modulators of Gene Expression

Epigenetic regulation of gene expression is essential in embryonic development and contributes to cancer pathology. We used a cell-based imaging assay that measures derepression of a silenced GFP reporter to identify novel classes of compounds involved in epigenetic regulation. This Locus Derepressi...

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Autors principals: Johnson, Ronald L., Huang, Wenwei, Jadhav, Ajit, Austin, Christopher P., Inglese, James, Martinez, Elisabeth D.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2330280/
https://ncbi.nlm.nih.gov/pubmed/18211814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2007.12.028
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