VMAT2 knockout mice: Heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity

The brain vesicular monoamine transporter (VMAT2) pumps monoamine neurotransmitters and Parkinsonism-inducing dopamine neurotoxins such as 1-methyl-4-phenyl-phenypyridinium (MPP(+)) from neuronal cytoplasm into synaptic vesicles, from which amphetamines cause their release. Amphetamines and MPP(+) e...

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Hauptverfasser: Takahashi, Nobuyuki, Miner, Lucinda L., Sora, Ichiro, Ujike, Hiroshi, Revay, Randal S., Kostic, Vladimir, Jackson-Lewis, Vernice, Przedborski, Serge, Uhl, George R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences of the USA 1997
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC23302/
https://ncbi.nlm.nih.gov/pubmed/9275230
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