Pyrimidinone-Peptoid Hybrid Molecules with Distinct Effects on Molecular Chaperone Function and Cell Proliferation

The Hsp70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast cancer. Hsp70 ATP hydrolysis is relatively weak, but is stimulated by J domain-containing proteins. We identified pyrimidinone-peptoid hybrid molecules that inhibit cell p...

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Autori principali: Wright, Christine M., Chovatiya, Raj J., Jameson, Nora E., Turner, David M., Zhu, Guangyu, Werner, Stefan, Huryn, Donna M., Pipas, James M., Day, Billy W., Wipf, Peter, Brodsky, Jeffrey L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2330198/
https://ncbi.nlm.nih.gov/pubmed/18164205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.12.014
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