Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum

Plasmodium falciparum, the Apicomplexan parasite that is responsible for the most lethal forms of human malaria, is exposed to radically different environments and stress factors during its complex lifecycle. In any organism, Hsp70 chaperones are typically associated with tolerance to stress. We the...

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Auteurs principaux: Chiang, Annette N., Valderramos, Juan-Carlos, Balachandran, Raghavan, Chovatiya, Raj J., Mead, Brian P., Schneider, Corinne, Bell, Samantha L., Klein, Michael G., Huryn, Donna M., Chen, Xiaojiang S., Day, Billy W., Fidock, David A., Wipf, Peter, Brodsky, Jeffrey L.
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775490/
https://ncbi.nlm.nih.gov/pubmed/19195901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.01.024
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