Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum

Plasmodium falciparum, the Apicomplexan parasite that is responsible for the most lethal forms of human malaria, is exposed to radically different environments and stress factors during its complex lifecycle. In any organism, Hsp70 chaperones are typically associated with tolerance to stress. We the...

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Main Authors: Chiang, Annette N., Valderramos, Juan-Carlos, Balachandran, Raghavan, Chovatiya, Raj J., Mead, Brian P., Schneider, Corinne, Bell, Samantha L., Klein, Michael G., Huryn, Donna M., Chen, Xiaojiang S., Day, Billy W., Fidock, David A., Wipf, Peter, Brodsky, Jeffrey L.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775490/
https://ncbi.nlm.nih.gov/pubmed/19195901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.01.024
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