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Early Beneficial Effect of Matrix Metalloproteinase Inhibition on BBB Permeability as Measured by MRI Countered by Impaired Long-Term Recovery After Stroke in Rat Brain

Proteolytic disruption of the extracellular matrix with opening of the blood-brain barrier (BBB) due to MMPs occurs in reperfusion injury after stroke. MMP inhibition blocks the early disruption of the BBB, but the long-term consequences of short-term MMP inhibition are not known. Recently, a method...

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Detalhes bibliográficos
Main Authors: Sood, Rohit, Taheri, Saeid, Candelario-Jalil, Eduardo, Estrada, Eduardo Y., Rosenberg, Gary A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2330167/
https://ncbi.nlm.nih.gov/pubmed/17700631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.jcbfm.9600534
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