Promoter-Wide Hypermethylation of the Ribosomal RNA Gene Promoter in the Suicide Brain

BACKGROUND: Alterations in gene expression in the suicide brain have been reported and for several genes DNA methylation as an epigenetic regulator is thought to play a role. rRNA genes, that encode ribosomal RNA, are the backbone of the protein synthesis machinery and levels of rRNA gene promoter m...

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Detalhes bibliográficos
Main Authors: McGowan, Patrick O., Sasaki, Aya, Huang, Tony C. T., Unterberger, Alexander, Suderman, Matthew, Ernst, Carl, Meaney, Michael J., Turecki, Gustavo, Szyf, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2330072/
https://ncbi.nlm.nih.gov/pubmed/18461137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002085
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