Haplotype analysis of TP53 polymorphisms, Arg72Pro and Ins16, in BRCA1 and BRCA2 mutation carriers of French Canadian descent

BACKGROUND: The TP53 polymorphisms Arg72Pro (Ex4+199 G>C) and Ins16 (IVS3+24 ins16) have been proposed to modify risk of breast cancer associated with germline BRCA1 and BRCA2 mutations. Allele frequencies of these polymorphisms were investigated to determine if they modify risk in BRCA mutation...

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Detalhes bibliográficos
Main Authors: Cavallone, Luca, Arcand, Suzanna L, Maugard, Christine, Ghadirian, Parviz, Mes-Masson, Anne-Marie, Provencher, Diane, Tonin, Patricia N
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2329651/
https://ncbi.nlm.nih.gov/pubmed/18402691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-96
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