Epidermal Growth Factor Abrogates Hypoxia-Induced Apoptosis in Cultured Human Trophoblasts through Phosphorylation of BAD Serine 112

We tested the hypothesis that epidermal growth factor (EGF) limits hypoxia-induced apoptosis in cultured human trophoblasts by phosphorylation of the proapoptotic protein Bcl-2-associated death promoter (BAD). Cytotrophoblasts were isolated from placentas of uncomplicated pregnancies at 38–40 wk ges...

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Bibliografiske detaljer
Main Authors: Humphrey, Rachel G., Sonnenberg-Hirche, Christina, Smith, Steven D., Hu, Chaobin, Barton, Aaron, Sadovsky, Yoel, Nelson, D. Michael
Format: Artigo
Sprog:Inglês
Udgivet: The Endocrine Society 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2329276/
https://ncbi.nlm.nih.gov/pubmed/18276761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-1253
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