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Effect of CD8(+) T-cell depletion on bronchial hyper-responsiveness and inflammation in sensitized and allergen-exposed Brown–Norway rats

We examined the role of CD8(+) T cells in a Brown–Norway rat model of asthma, using a monoclonal antibody to deplete CD8(+) T cells. Ovalbumin (OA)-sensitized animals were given anti-CD8 antibody (0·5 mg/rat) intravenously 1 week prior to exposure to 1% OA aerosol and were studied 18–24 hr after aer...

詳細記述

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書誌詳細
主要な著者: Huang, T-J, Macary, P A, Kemeny, D M, Chung, K F
フォーマット: Artigo
言語:Inglês
出版事項: Blackwell Science Inc 1999
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2326765/
https://ncbi.nlm.nih.gov/pubmed/10233723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.1999.00699.x
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