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Mutations of N-terminal regions render the retinoblastoma protein insufficient for functions in development and tumor suppression.

To assess biological roles of the retinoblastoma protein (RB), four independent transgenic mouse lines expressing human RB with different deletions in the N-terminal region (RBdeltaN) were generated and compared with mice expressing identically regulated, full-length RB. Expression of both RB and RB...

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Detalles Bibliográficos
Publicado en:Mol Cell Biol
Principais autores: Riley, D J, Liu, C Y, Lee, W H
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 1997
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232590/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9372965/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.12.7342
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