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Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53

The p53 tumor suppressor gene has been shown to play an important role in determining cell fate. Overexpression of wild-type p53 in tumor cells has been shown to lead to growth arrest or apoptosis. Previous studies in fibroblasts have provided indirect evidence for a link between p53 and senescence....

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Bibliografiska uppgifter
Huvudupphovsmän: Sugrue, Mary M., Shin, Deug Y., Lee, Sam W., Aaronson, Stuart A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences of the USA 1997
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC23243/
https://ncbi.nlm.nih.gov/pubmed/9275177
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