Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53
The p53 tumor suppressor gene has been shown to play an important role in determining cell fate. Overexpression of wild-type p53 in tumor cells has been shown to lead to growth arrest or apoptosis. Previous studies in fibroblasts have provided indirect evidence for a link between p53 and senescence....
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
1997
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23243/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9275177/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.18.9648 |
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