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HMG-box domain stimulation of RAG1/2 cleavage activity is metal ion dependent
BACKGROUND: RAG1 and RAG2 initiate V(D)J recombination by assembling a synaptic complex with a pair of antigen receptor gene segments through interactions with their flanking recombination signal sequence (RSS), and then introducing a DNA double-strand break at each RSS, separating it from the adjac...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2324110/ https://ncbi.nlm.nih.gov/pubmed/18380906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-9-32 |
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