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The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k.

Employing specific inhibitors and docking-site mutants of growth factor receptors, recent studies have indicated that the insulin-induced increase in 40S ribosomal protein S6 and initiation factor 4E binding protein 1 (4E-BP1) phosphorylation is mediated by the mTOR/FRAP-p70s6k signal transduction p...

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Udgivet i:Mol Cell Biol
Principais autores: von Manteuffel, S R, Dennis, P B, Pullen, N, Gingras, A C, Sonenberg, N, Thomas, G
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232392/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9271419/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.9.5426
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