Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity.

A short C-terminal sequence that is deleted in the v-ErbA oncoprotein and conserved in members of the nuclear receptor superfamily is required for normal biological function of its normal cellular counterpart, the thyroid hormone receptor alpha (T3R alpha). We carried out an extensive mutational ana...

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Autores principales: Saatcioglu, F, Lopez, G, West, B L, Zandi, E, Feng, W, Lu, H, Esmaili, A, Apriletti, J W, Kushner, P J, Baxter, J D, Karin, M
Formato: Artigo
Lenguaje:Inglês
Publicado: 1997
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC232321/
https://ncbi.nlm.nih.gov/pubmed/9234725
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