STAT3 and STAT1 mediate IL-11–dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice

Deregulated activation of STAT3 is frequently associated with many human hematological and epithelial malignancies, including gastric cancer. While exaggerated STAT3 signaling facilitates an antiapoptotic, proangiogenic, and proproliferative environment for neoplastic cells, the molecular mechanisms...

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Bibliographic Details
Main Authors: Ernst, Matthias, Najdovska, Meri, Grail, Dianne, Lundgren-May, Therese, Buchert, Michael, Tye, Hazel, Matthews, Vance B., Armes, Jane, Bhathal, Prithi S., Hughes, Norman R., Marcusson, Eric G., Karras, James G., Na, Songqing, Sedgwick, Jonathon D., Hertzog, Paul J., Jenkins, Brendan J.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2008
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323192/
https://ncbi.nlm.nih.gov/pubmed/18431520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34944
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