STAT3 negatively regulates thyroid tumorigenesis

Although tyrosine-phosphorylated or activated STAT3 (pY-STAT3) is a well-described mediator of tumorigenesis, its role in thyroid cancer has not been investigated. We observed that 63 of 110 (57%) human primary papillary thyroid carcinoma (PTC) cases expressed nuclear pY-STAT3 in tumor cells, prefer...

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Detalhes bibliográficos
Main Authors: Couto, Joana Pinto, Daly, Laura, Almeida, Ana, Knauf, Jeffrey A., Fagin, James A., Sobrinho-Simões, Manuel, Lima, Jorge, Máximo, Valdemar, Soares, Paula, Lyden, David, Bromberg, Jacqueline F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435219/
https://ncbi.nlm.nih.gov/pubmed/22891351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201232109
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