SARS-Coronavirus Replication/Transcription Complexes Are Membrane-Protected and Need a Host Factor for Activity In Vitro

SARS-coronavirus (SARS-CoV) replication and transcription are mediated by a replication/transcription complex (RTC) of which virus-encoded, non-structural proteins (nsps) are the primary constituents. The 16 SARS-CoV nsps are produced by autoprocessing of two large precursor polyproteins. The RTC is...

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Bibliographic Details
Main Authors: van Hemert, Martijn J., van den Worm, Sjoerd H. E., Knoops, Kèvin, Mommaas, A. Mieke, Gorbalenya, Alexander E., Snijder, Eric J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2322833/
https://ncbi.nlm.nih.gov/pubmed/18451981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000054
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