Zn(2+) Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

Increasing the intracellular Zn(2+) concentration with zinc-ionophores like pyrithione (PT) can efficiently impair the replication of a variety of RNA viruses, including poliovirus and influenza virus. For some viruses this effect has been attributed to interference with viral polyprotein processing...

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Detalhes bibliográficos
Principais autores: te Velthuis, Aartjan J. W., van den Worm, Sjoerd H. E., Sims, Amy C., Baric, Ralph S., Snijder, Eric J., van Hemert, Martijn J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2973827/
https://ncbi.nlm.nih.gov/pubmed/21079686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001176
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