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Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms.

Glucocorticoids inhibit proliferation of many cell types, but the events leading from the activated glucocorticoid receptor (GR) to growth arrest are not understood. Ectopic expression and activation of GR in human osteosarcoma cell lines U2OS and SAOS2, which lack endogenous receptors, result in a...

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Udgivet i:Mol Cell Biol
Principais autores: Rogatsky, I, Trowbridge, J M, Garabedian, M J
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232171/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9154817/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.6.3181
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