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Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation.

Epidermal growth factor (EGF) induces tyrosine phosphorylation of the Shc adapter protein, which plays an important role in EGF-stimulated mitogenesis. Shc stimulates Ras/mitogen-activated protein kinase (MAPK) through forming a complex with Grb2 at the phosphorylated tyrosine (Y) residue 317. In th...

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Библиографические подробности
Главные авторы: Gotoh, N, Toyoda, M, Shibuya, M
Формат: Artigo
Язык:Inglês
Опубликовано: 1997
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC232029/
https://ncbi.nlm.nih.gov/pubmed/9121430
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