Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation.

Míreanna Comhchosúla

• A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3.
  le: Gotoh, N, et al.
  Foilsithe: (1996)
• Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity.
  le: Gotoh, N, et al.
  Foilsithe: (1994)
• Protein Phosphatase 2A Forms a Molecular Complex with Shc and Regulates Shc Tyrosine Phosphorylation and Downstream Mitogenic Signaling
  le: Ugi, Satoshi, et al.
  Foilsithe: (2002)
• Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras.
  le: Pronk, G J, et al.
  Foilsithe: (1994)
• Mitogenic activation of the Ras guanine nucleotide exchange factor in NIH 3T3 cells involves protein tyrosine phosphorylation.
  le: Li, B Q, et al.
  Foilsithe: (1993)