Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells.

Mice made insulin receptor substrate 1 (IRS-1) deficient by targeted gene knockout exhibit growth retardation and abnormal glucose metabolism due to resistance to the actions of insulin-like growth factor 1 (IGF-1) and insulin (E. Araki et al., Nature 372:186-190, 1994; H. Tamemoto et al., Nature 37...

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Publicat a:	Mol Cell Biol
Autors principals:	Brüning, J C, Winnay, J, Cheatham, B, Kahn, C R
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis 1997
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231877/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9032279/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.3.1513
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