Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.

eIF2B is a five-subunit guanine nucleotide exchange factor that is negatively regulated by phosphorylation of the alpha subunit of its substrate, eIF2, leading to inhibition of translation initiation. To analyze this regulatory mechanism, we have characterized 29 novel mutations in the homologous eI...

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Vydáno v:	Mol Cell Biol
Hlavní autoři:	Pavitt, G D, Yang, W, Hinnebusch, A G
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 1997
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231855/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9032257/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.3.1298
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