Still looking for the magic spot: the crystallographically-defined binding site for ppGpp on RNA polymerase is unlikely to be responsible for rRNA transcription regulation

Identification of the RNA polymerase (RNAP) binding site for ppGpp, a central regulator of bacterial transcription, is crucial for understanding its mechanism of action. A recent high resolution x-ray structure defined a ppGpp binding site on T. thermophilus RNAP. We report here effects of ppGpp on...

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Detalhes bibliográficos
Main Authors: Vrentas, Catherine E., Gaal, Tamas, Berkmen, Melanie B., Rutherford, Steven T., Haugen, Shanil P., Ross, Wilma, Gourse, Richard L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2317782/
https://ncbi.nlm.nih.gov/pubmed/18272182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.01.042
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