Direct interaction of Gβγ with a C-terminal Gβγ-binding domain of the Ca(2+) channel α(1) subunit is responsible for channel inhibition by G protein-coupled receptors

Several classes of voltage-gated Ca(2+) channels (VGCCs) are inhibited by G proteins activated by receptors for neurotransmitters and neuromodulatory peptides. Evidence has accumulated to indicate that for non-L-type Ca(2+) channels the executing arm of the activated G protein is its βγ dimer (Gβγ)....

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Hlavní autoři: Qin, Ning, Platano, Daniela, Olcese, Riccardo, Stefani, Enrico, Birnbaumer, Lutz
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences of the USA 1997
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC23172/
https://ncbi.nlm.nih.gov/pubmed/9238069
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