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Direct interaction of Gβγ with a C-terminal Gβγ-binding domain of the Ca(2+) channel α(1) subunit is responsible for channel inhibition by G protein-coupled receptors

Several classes of voltage-gated Ca(2+) channels (VGCCs) are inhibited by G proteins activated by receptors for neurotransmitters and neuromodulatory peptides. Evidence has accumulated to indicate that for non-L-type Ca(2+) channels the executing arm of the activated G protein is its βγ dimer (Gβγ)....

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Qin, Ning, Platano, Daniela, Olcese, Riccardo, Stefani, Enrico, Birnbaumer, Lutz
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23172/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9238069/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.16.8866
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