Direct interaction of Gβγ with a C-terminal Gβγ-binding domain of the Ca(2+) channel α(1) subunit is responsible for channel inhibition by G protein-coupled receptors
Several classes of voltage-gated Ca(2+) channels (VGCCs) are inhibited by G proteins activated by receptors for neurotransmitters and neuromodulatory peptides. Evidence has accumulated to indicate that for non-L-type Ca(2+) channels the executing arm of the activated G protein is its βγ dimer (Gβγ)....
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
1997
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23172/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9238069/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.16.8866 |
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