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c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein.
The c-ABL tyrosine kinase is activated following either the loss or mutation of its Src homology domain 3 (SH3), resulting in both increased autophosphorylation and phosphorylation of cellular substrates and cellular transformation. This suggests that the SH3 domain negatively regulates c-ABL kinase...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
1996
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC231708/ https://ncbi.nlm.nih.gov/pubmed/8943360 |
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