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Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function.

Biochemical and genetic evidence has implicated two families of protein tyrosine kinases (PTKs), the Src- and Syk-PTKs, in T- and B-cell antigen receptor signaling. ZAP-70 is a member of the Syk-PTKs that associates with the T-cell antigen receptor and undergoes tyrosine phosphorylation following re...

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Udgivet i:Mol Cell Biol
Principais autores: Kong, G, Dalton, M, Wardenburg, J B, Straus, D, Kurosaki, T, Chan, A C
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231504/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8756661/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.9.5026
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