Inhibition of p53-mediated growth arrest by overexpression of cyclin-dependent kinases.

Rat fibroblasts transformed by a temperature-sensitive mutant of murine p53 undergo a reversible growth arrest in G1 at 32.5 degrees C, the temperature at which p53 adopts a wild-type conformation. The arrested cells contain inactive cyclin-dependent kinase 2 (cdk2) despite the presence of high leve...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Latham, K M, Eastman, S W, Wong, A, Hinds, P W
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 1996
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231443/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8754845/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.8.4445
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