A double-strand break within a yeast artificial chromosome (YAC) containing human DNA can result in YAC loss, deletion or cell lethality.

Documenti analoghi

• SIR Functions Are Required for the Toleration of an Unrepaired Double-Strand Break in a Dispensable Yeast Chromosome
  di: Bennett, Craig B., et al.
  Pubblicazione: (2001)
• Meiotic double-strand breaks in yeast artificial chromosomes containing human DNA.
  di: Ira, G, et al.
  Pubblicazione: (1998)
• Lethality induced by a single site-specific double-strand break in a dispensable yeast plasmid.
  di: Bennett, C B, et al.
  Pubblicazione: (1993)
• Analysis of chromosome 21 yeast artificial chromosome (YAC) clones.
  di: Tassone, F, et al.
  Pubblicazione: (1992)
• Recombination during transformation as a source of chimeric mammalian artificial chromosomes in yeast (YACs).
  di: Larionov, V, et al.
  Pubblicazione: (1994)